X-ray Crystallography Core Laboratory

Department of Biochemistry

Director: P. John Hart, Ph.D.  Faculty Web Site

The X-ray Crystallography Core Laboratory at the University of Texas Health Science Center at San Antonio offers state-of-the-art macromolecular X-ray crystallographic instrumentation operating on a collaborative use basis. The equipment infrastructure of the facility presently includes two complete X-ray crystallography systems:

1) Rigaku R-AXIS HTC imaging plate area detector with VariMax HighFlux optics mounted on a high-flux MIcroMax 007HF generator with an X-STREAM cryogenic crystal cooling system

2) Rigaku R-AXIS HTC imaging plate area detector with VariMax HighRes optics mounted on a high-flux MIcroMax 007HF generator with an X-STREAM cryogenic crystal cooling system

The improved brilliance of the 007HF equipped with VariMax optics relative to conventional home lab X-ray sources gives researchers the in-house capability to work with very small or poorly diffracting crystals. Computational hardware (Intel Quad-core Linux workstations) and software (CNS, CCP4, COOT, d*TREK, HKL-2000, PHENIX, SHARP, SHELX, etc.) are also in place enabling the complete protein structure determination and refinement process to be accomplished in relatively short order. 

 

Director:                     P. John Hart, Ph.D.

                                  Office: 210-567-0751

                                  FAX: 210-567-6595

                                  E-mail: pjhart@biochem.uthscsa.edu

 

Technical Director:    Alex Taylor, Ph.D.

                                  Office: 210-567-3781

                                  FAX: 210-567-6595

                                  E-mail: taylor@biochem.uthscsa.edu

 

Operator:                   Nick Criscimagna

                                  Office: 210-567-6971

                                  FAX: 210-567-6595

                                  E-mail: criscimagna@uthscsa.edu

 

 

 

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