2008
Cao, X., Antonyuk, S., Seetharaman, S.V., Whitson, L.J., Taylor, A.B., Holloway, S.P., Strange, R.W., Doucette, P.A., Valentine, J.S., Tiwari, A., Hayward, L.J., Padua, S., Cohlberg, J.A., Hasnain,S.S and Hart. P.J. Structures of the G85R variant of SOD1 in Familial ALS. J. Biol. Chem. 283, 16169-16177. PDB: 2VR6, 2VR7, 2VR8, 3CQP, 3CQQ
Taylor, A.B., Meyer, B., Leal, B.Z., Kötter, P., Schirf, V., Demeler, B., Hart, P.J., Entian, K.D. and Wöhnert, J. The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res. 36, 1542-1554. PDB: 3BBD, 3BBE, 3BBH
Taylor, A.B., Hu, G., Hart, P.J. and McAlister-Henn, L. Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase. J. Biol. Chem. 283,10872-10880. PDB: 3BLV, 3BLW, 3BLX
Groppe, J., Hinck, C.S., Samavarchi-Tehrani, P., Zubieta, C., Schuermann, J.P., Taylor, A.B., Schwarz, P.M., Wrana, J.L. and Hinck, A.P. Cooperative assembly of TGF-β superfamily signaling complexes Is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol. Cell. 29, 157-168. PDB: 2PJY
2007
Jiang, J., Maes, E.G., Taylor, A.B., Wang, L., Hinck, A.P., Lafer, E.M. and Sousa, R. Structural basis of J cochaperone binding and regulation of Hsp70. Mol. Cell. 28, 422-433. PDB: 2QW9, 2QWL, 2QWM, 2QWN, 2QWO, 2QWP, 2QWQ, 2QWR
Quintanar, L., Stoj, C., Taylor, A.B., Hart, P.J., Kosman, D.J. and Solomon, E.I. Shall we dance? How a multicopper oxidase chooses its electron transfer partner. Acc. Chem. Res. 40, 445-452.
Hu, G., Taylor, A.B., McAlister-Henn, L. and Hart, P.J. (2007). Crystal structure of the yeast nicotinamidase Pnc1p. Arch. Biochem. Biophys. 461, 66-75. PDB: 2H0R
Wang, J., Caruano-Yzermans, A., Rodriguez, A., Schuermann, J.P., Slunt, H.H., Cao, X., Gitlin, J., Hart, P.J. and Borchelt, D.R. (2007). Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. J. Biol. Chem. 282, 345-352.
2006
Heitmann, L.M., Taylor, A.B., Hart, P.J. and Urbach, A.R. (2006). Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host. J. Am. Chem. Soc. 128, 12574-12581.
Carroll, M.C., Outten, C.E., Proescher, J.B., Rosenfeld, L., Watson, W.H., Whitson, L.J., Hart, P.J., Jensen, L.T. and Culotta V.C. (2006). The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase. J. Biol. Chem. 281, 28648-28656.
Hart, P.J. (2006). Pathogenic superoxide dismutase structure, folding, aggregation and turnover. Curr. Opin. Chem. Biol. 10, 131-138.
Jiang, J., Lafer, E.M. and Sousa, R. (2006) Crystallization of a functionally intact Hsp70 chaperone. Acta Cryst. F62, 39-43.
2005
Taylor, A.B., Stoj, C.S., Ziegler, L., Kosman, D.J. and Hart, P.J. (2005). The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p. Proc. Natl. Acad. Sci. U.S.A. 102, 15459-15464. PDB: 1ZPU
Di Noto, L., Whitson, L.J., Cao, X., Hart, P.J. and Levine, R.L. (2005). Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis. J. Biol. Chem. 280, 39907-39913.
Jiang, J., Prasad, K., Lafer, E.M. and Sousa, R. (2005) Structural basis of interdomain communication in the Hsc70 chaperone. Mol. Cell 20, 513-524. PDB: 1YUW
Whitson, L.J. and Hart, P.J. (2005) "Copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis." in: Metal Ions in Biological Systems. Vol 45 (Sigel, A., Sigel, H, and Sigel, R.O.K. eds) John Wiley & Sons Ltd., Chichester, UK.
Galaleldeen, A. and Hart, P.J. (2005) "Human copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis" in: Protein Misfolding, Aggregation and Conformational Diseases. (Uversky, V.N., and Fink, A.L eds) Kluwer Academic/Plenum New York, U.S.A.
Hart, P.J. and Valentine, J.S. (2005). "Metal-deficient copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis" in Medicinal Inorganic Chemistry. (Sessler, J.L., Doctrow, S.R., McMurray, T.S. and Lippard, S.J. eds). ACS Books, Washington D.C., U.S.A. pp. 348-365.
Hart, P.J., Nersissian, A.M. and DeBeer, G.S. (2005). "Copper Proteins with Type I Sites" in Encyclopedia of Inorganic Chemistry, Vol. 2. (King, R.B., Atwood, D.A., Crabtree, R.H., Lukehart, C.M. and Scott, R.A. eds.) John Wiley & Sons, Ltd. Chichester, U.K.
Hu, G., Taylor, A.B., McAlister-Henn, L. and Hart, P.J. (2005). Crystallization and preliminary X-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase. Acta Crystallogr. F61, 486-488.
Antonyuk, S., Elam, J.S., Hough, M.A., Strange, R.W., Doucette, P.A., Rodriguez, J.A., Hayward, L.J., Valentine, J.S., Hart, P.J. and Hasnain, S.S. (2005). Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. Protein Sci. 14, 1201-1213.
2004
Doucette, P.A., Whitson, L.J., Cao, X., Schirf, V., Demeler, B., Valentine, J.S., Hansen, J.C. and Hart, P.J. (2004). Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant: Insights into the molecular basis for dimer stability. J. Biol. Chem. 279, 54558-54566.
Laliberte, J., Whitson, L.J., Beaudoin, J., Holloway, S.P., Hart, P.J. and Labbe, S. (2004). The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways. J. Biol. Chem. 279, 28744-28755.
Hough, M.A., Grossmann, J.G., Antonyuk, S.V., Strange, R.W., Doucette, P.A., Rodriguez, J.A., Whitson, L.J., Hart, P.J., Hayward, L.J., Valentine, J.S. and Hasnain S.S. (2004). Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proc. Natl. Acad. Sci. U.S.A. 101, 5976-5981.
2003
Elam, J.S., Taylor, A.B., Strange, R., Antonyuk, S., Doucette, P.A., Rodriguez, J.A., Hasnain, S.S., Hayward, L.J., Valentine, J.S., Yeates, T.O. and Hart, P.J. (2003). Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutants linked to familial ALS. Nat. Struct. Biol. 10, 461-467. PDB: 1OEZ, 1OZT, 1OZU
Elam, J.S., Malek, K., Rodriguez, J.A., Doucette, P.A., Taylor, A.B., Hayward, L.J., Cabelli, D.E., Valentine, J.S. and Hart, P.J. (2003). An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase. J. Biol. Chem. 278, 21032-21039. PubMed PDB: 1P1V
Taylor, A.B., Benglis, Jr., D.M., Dhandayuthapani, S. and Hart, P.J. (2003). Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine. J. Bacteriol. 185, 4119-4126. PDB: 1NWA
Jiang, J., Taylor, A.B., Prasad, K., Ishikawa-Brush, Y., Hart, P.J., Lafer, E.M., and Sousa, R. (2003). Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface. Biochemistry. 42, 5748-53. PDB:1NZ6
Strange, R., Antonyuk, S., Hough, M.A., Doucette, P.A., Rodriguez, J.A., Hart, P.J., Hayward, L.J., Valentine, J.S. and Hasnain, S.S. (2003). The structure of holo and metal deficient wild type human Cu,Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. J. Mol. Biol. 328, 877-91. PDB: 1HL4, 1HL5
Valentine, J.S. and Hart, P.J. (2003). Misfolded CuZnSOD and ALS. Proc. Natl. Acad. Sci. U.S.A. 100, 3617-3622.
2002
Hart, P.J., Deep, S., Taylor, A.B., Shu, Z., Hinck, C.S., and Hinck, A.P. (2002). Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3. Nat. Struct. Biol. 9, 203-208. PDB: 1KTZ
Elam, J.S., Thomas, S.T., Holloway, S.P., Taylor, A.B., and Hart, P.J. (2002). Copper Chaperones. In: Advances in Protein Chemistry. (Valentine, J.S. and Gralla, E.B., eds.) Academic Press, San Diego, CA. pp. 151-219.
Pascal, J.M., Hart, P.J., Hecht, N.B. and Robertus, J.D. (2002). Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. J. Mol. Biol. 319, 1049-1057. PDB: 1KEY
2001
Nersissian, A.M., Hart, P.J., and Valentine, J.S. (2001). Stellacyanin, a member of the phytocyanin family of plant proteins. In: Handbook of Metalloproteins (Messerschmidt, A., Huber, R., Poulos, T., and Wieghardt, K., eds) John Wiley and Sons, Ltd., Chichester, England. pp. 1219-1234.
2000
Hall, L.T., Sanchez, R.J., Holloway, S.P., Zhu, H., Stine, J.E., Lyons, T.J., Demeler, B., Schirf, V., Hansen, J.C., Nersissian, A.M., Valentine, J.S., and Hart, P.J. (2000). X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery. Biochemistry. 39, 3611-3623. PDB: 1EJ8
Zhu H., Shipp E., Sanchez R.J., Liba A., Stine J.E., Hart P.J., Gralla E.B., Nersissian A.M., Valentine J.S. (2000). Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism. Biochemistry. 39, 5413-5421.
1999
Valentine, J.S., Hart, P.J., Gralla, E.B. (1999). "Copper-zinc superoxide dismutase and ALS." In: Advances in Experimental Medicine and Biology: Copper Transport and its Disorders: Molecular and Cellular Aspects (Leone, A., and Mercer, J.F.B. eds.) Plenum Press, New York, New York. pp. 193-203.
